Philip M Potter Selected Research

Carboxylesterase (Hydrolase S)

3/2017	Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma.
9/2010	Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme.
4/2010	Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.
1/2009	Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.
1/2008	Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.
1/2007	Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.
12/2005	Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.
8/2005	Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.
8/2004	Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
6/2004	Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.

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Philip M Potter Research Topics

Disease

29	Neoplasms (Cancer) 01/2020 - 05/2002
6	Neuroblastoma 01/2020 - 09/2002
5	Glioma (Gliomas) 12/2013 - 11/2003
4	Colonic Neoplasms (Colon Cancer) 12/2005 - 08/2003
3	Diarrhea 06/2009 - 06/2004
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2020 - 01/2013
2	Melanoma (Melanoma, Malignant) 01/2019 - 09/2010
2	Brain Neoplasms (Brain Tumor) 12/2013 - 08/2005
2	Alzheimer Disease (Alzheimer's Disease) 03/2013 - 04/2003
2	Poisoning 03/2011 - 04/2010
2	Breast Neoplasms (Breast Cancer) 01/2008 - 09/2005
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018
1	Heart Failure 01/2018
1	Immune System Diseases (Immune Disorders) 01/2018
1	Rhabdomyosarcoma 01/2018
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2018
1	Ischemic Stroke 01/2013
1	Hypertension (High Blood Pressure) 01/2013
1	Atherosclerosis 01/2009
1	Glioblastoma (Glioblastoma Multiforme) 01/2008
1	Organophosphate Poisoning 05/2007
1	Body Weight (Weight, Body) 10/2006
1	Narcotic-Related Disorders 04/2003

Drug/Important Bio-Agent (IBA)

20	Irinotecan (Camptosar)FDA LinkGeneric 03/2017 - 09/2002
17	ProdrugsIBA 03/2017 - 09/2002
14	EnzymesIBA 10/2016 - 05/2002
13	Pharmaceutical PreparationsIBA 01/2018 - 04/2003
13	Carboxylesterase (Hydrolase S)IBA 03/2017 - 09/2002
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2004
4	Biological ProductsIBA 01/2020 - 11/2003
4	Carboxylic Ester HydrolasesIBA 12/2013 - 06/2006
4	CamptothecinIBA 12/2005 - 08/2003
3	Nerve AgentsIBA 03/2011 - 05/2007
3	CholesterolIBA 01/2009 - 04/2003
2	Clopidogrel (Plavix)FDA Link 03/2020 - 01/2009
2	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 06/2004
2	RNA (Ribonucleic Acid)IBA 01/2019 - 06/2011
2	EsterasesIBA 09/2012 - 12/2005
1	Cytotoxins (Cytolysins)IBA 01/2020
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019
1	Anaplastic Lymphoma KinaseIBA 01/2018
1	CrizotinibIBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	5- ((4- (5- (7,7- dimethyl- 1,6- dioxaspiro(2.5)octan- 5- yl)- 3- methylpenta- 2,4- dien- 1- yl)cyclohexyl)amino)- 5- oxopent- 3- en- 2- yl methylcarbamateIBA 08/2015
1	ChromatinIBA 04/2014
1	sudemycin EIBA 04/2014
1	CarbamatesIBA 03/2013
1	Dexamethasone (Maxidex)FDA LinkGeneric 09/2012
1	PalmitatesIBA 09/2012
1	Conditioned Culture MediaIBA 09/2010
1	Tissue Inhibitor of Metalloproteinase-2IBA 09/2010
1	Interleukin-6 (Interleukin 6)IBA 09/2010
1	CytokinesIBA 09/2010
1	Interleukin-8 (Interleukin 8)IBA 09/2010
1	Chemotactic FactorsIBA 09/2010
1	Cholinesterases (Cholinesterase)IBA 04/2010
1	Agrochemicals (Agricultural Chemicals)IBA 01/2009
1	Oseltamivir (Tamiflu)FDA Link 01/2009
1	LipidsIBA 01/2009
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2009
1	Formaldehyde (Formol)FDA Link 01/2008
1	doxazolidineIBA 01/2008
1	Tuberculin (PPD)IBA 01/2008
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2008
1	Complementary DNA (cDNA)IBA 01/2007
1	fenvalerateIBA 10/2006
1	decamethrin (deltamethrin)IBA 10/2006
1	PoisonsIBA 12/2005
1	Cholinergic Agents (Cholinergics)IBA 12/2005
1	Atropine FDA LinkGeneric 12/2005
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 12/2005
1	EstersIBA 09/2005
1	Tamoxifen FDA LinkGeneric 09/2005
1	benzilIBA 09/2005
1	ethyl acetateIBA 09/2005
1	mevastatin (CS 500)IBA 09/2005
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/2005
1	Cytochrome P-450 CYP2B1 (PROD)IBA 08/2005
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 11/2003
1	dl1520 (ONYX-015)IBA 10/2003
1	AcetylcholinesteraseIBA 04/2003
1	Tacrine (Cognex)FDA Link 04/2003
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 09/2002

Therapy/Procedure

14	Therapeutics 12/2013 - 09/2002
5	Drug Therapy (Chemotherapy) 01/2020 - 09/2002
1	Contraception (Birth Control) 01/2018
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2013
1	Radiotherapy 09/2010
1	Stem Cell Transplantation 09/2002